An autoimmune disease is a problem where the body immunity n turns against itself; polyarteritis nodosa (PAN) is one such unusual, autoimmune disorder. The pathophysiology of this disease usually calls for inflammation of the tiny arteries within the body. This has an effect on mainly the epidermis, joints, peripheral nerves, kidneys and intestines, moreover causes symptoms such as fever, night sweats, losing weight, muscle and joint pains, and skin ulceration or nodule formation.