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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, given that they also suffer from weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes established that patients had an average weight loss of four.1% in contrast to participants who have been given placebos) throughout a 12- month period, while an outside study involving patients with diabetes type 2 had the average weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the those who go through it you ought to err on the side of caution and let the FDA do its job and demand some study be done in order that the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on his or her medications.

Researchers found out that participants investing in this drug to get a year, lost excess weight within 4 weeks and have kept the load off during the entire 56 weeks from the study. Contrave is really a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of many active ingredient, that might make them more efficient and safer.

Combo-pilling may be the newest fad or also the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that since right now there are no long term prescription diet pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise hypertension and pulse rate, and shouldn't be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high blood pressure levels, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

An independent report published by Gant Daily in April also stated that naltrexone also works well with kleptomaniacs and gambling addicts, as well. Citing research through the University of Minnesota School of Medicine, Gant Daily reported the drug conditions kleptomaniacs and chronic gamblers in the same manner with alcohol and opioid addicts'by blocking the effects of endorphins, that your brain releases when experiencing craving or compulsions.